warren sherman

Warren V. Sherman, Ph.D.
Professor of Chemistry, Emeritus

MBRS Programs Coordinator

MBRS Program. Since 1991 I have been Program Director of the Minority Biomedical Research Support (MBRS) Programs which are among the largest research grants in the sciences at Chicago State University (CSU). The MBRS programs are funded by the National Institutes of Health (NIH).  CSU receives funding for two MBRS Programs:  SCORE was an institutional research program that supported faculty research projects with funding through 2011. It has subsequently been re-defined by the NIH to support individual faculty-led projects. RISE is a training grant preparing students for careers in biomedical research and is funded through 2013.  Since 2000, the MBRS Programs have provided Chicago State with research and research training funds in excess of $14 million.
          New NIH guidelines exclude emeritus faculty from the role of Program Director for the MBRS programs and currently Dr. Devi Potluri, Professor of Biology and Interim Chair of the Biological Sciences Dept. is the PD for RISE.  I have assumed the the day-today direction of the program and supervision of the operations of the MBRS Office in the role of MBRS Programs Coordinator.

An competing continuation application to renew the RISE Program through 2017 is currently under review..

Teaching.My teaching has been primarily in areas of organic chemistry and instrumental methods. 

Research. My research has received financial support from the federal government (National Institutes of Health, National Science Foundation), the American Chemical Society, the European Molecular Biology Organization and the private sector (International Minerals and Chemicals, Inc., Blum-Kovler Foundation).  These activities have  resulted in 50 publications in peer-reviewed scientific journals and a larger number of presentations at professional conferences.  A significant proportion of these included CSU students as coauthors. My research interests include

  • photochemistry and photobiology of biological and synthetic pigments, including rhodopsins,
  • protein structural analysis using spectrophotometric techniques,
  • photochemistry and high-energy radiation chemistry of organic compounds in solution,
  • bacterial phototaxis and chemotaxis, and
  • radiation safety and biohazards. 

Awards & Honors:

Fulbright Fellowship, 1961-2.
National Academy of Science Fellowship, US Army Natick Laboratories, Natick, MA, 1962-4.  
 European Molecular Biology Fellowship at University of Salford, UK,  and Weizmann Institute,  Israel, 1975-6.  
Visiting Professor of Physics, NSF Faculty Development Fellowship, Illinois Institute of Technology, 1979-80. 
Faculty Excellence Awards, Chicago State University, 1991, 1992, 1993,1995, and 1999.

Education/Training:

INSTITUTION AND LOCATION

DEGREE

FIELD OF STUDY

King’s College,   University  of London

B.Sc. (Hons.)

Chemistry

 King’s College, University of London

Ph.D.

Organic Chemistry

 Brandeis University

Postdoctoral

Photochemistry

Research Grants & Support (Director/Principal Investigator):

DATES

AGENCY*

ABBREVIATED TITLE

BUDGET** 

2009-13

NIH-NIGMS

MBRS-RISE Student Development Program (Program Coordinator)

$1.1 million

2007-11

NIH-NIGMS

MBRS-SCORE Institutional Biomedical Research Program (PD through 2008; coordinator 2008-2011).

$2.7 million

2003-7

NIH-NIGMS

MBRS-SCORE Institutional Biomedical Research Program (PD).

$4.2 million

2003-8

NIH-NIGMS

MBRS-RISE Student Development Program (PD).

$2.7 million

1999-2003

NIH-NIGMS

MBRS-SCORE Institutional Biomedical Research Program (PD).

$2.4 million

1999-2003

NIH-NIGMS

MBRS-RISE Student Development Program (PD).

$2.6 million

1999-2001

NIH-NIGMS

MBRS-RISE Communications Technology Supplement (PD).

$246,000

2001-4

NSF

Virtual Experiments for Biomedical Engineering Education – joint project with Illinois Institute of Techno­logy (Dr. Ali Cinar,  PD).

$39,000

1995-9

NIH-NIGMS

MBRS Institutional Research Grant (PD).

$3.5 million

1995-9

NIH-NIGMS

MBRS research project PI: Design and function of sensitizers for photodynamic action.

$417,376

1985-1998

 

ACS

SEED grant for disadvantaged high-school student summer research experience.

  $6,000 (per year)

1993-6

NIH-NCRR

Minority High School Student Research Apprentice Program.

$10,000 (per year)

1991-5

NIH-NIGMS

MBRS research project PI: Design and function of sensitizers for photodynamic action.

$350,000

1987-91

NIH-NIGMS

MBRS research project PI: Photochemistry of bacteriorhodopsin

$311,203

1983-7

NIH-NIGMS

MBRS research project PI: Photochemistry of bacteriorhodopsin

$96,782

1977-82

NIH-NIGMS

MBRS research project PI: Photochemistry of bacteriorhodopsin

$48,362

1981-4

NIH - NEI

RO1 research grant:  Photochemistry of visual pigments (renewal)

$350,000

1977-81

NIH - NEI

RO1 research grant:  Photochemistry of visual pigments.

$350,000

1984

NIH

Capital instrumentation (FTIR spectrophotometer)

$50,278

1981

NSF

Capital instrumentation (UV-visible scanning spectrophotometer)

$27,800

1988-90

 

IMC

Industrial research grant (I­nternational Minerals & Chemicals) Corp.: Conformational analysis of  somatotropins.

$22,000

1980-1

NSF

Faculty Development Award (sabbatical at Illinois Institute of Technology).

Salary

1975-6

EMBO

Visiting Research Professor (University of Salford and Weizmann Institute)

Travel & salary

1969-71

ACS

Petroleum Research Fund:  Radiolysis of organic compounds in solution.

  $25,000

* NIH - National Institutes of Health;   NIGMS - National Institute of General Medical Sciences;  ACS - American  Chemical Society; NCI - National Cancer Institute;  MBRS - Minority Biomedical Research Support; SEED - Summer Research Experience for Economically Disadvantaged;  NSF - National Science Foundation; EMBO - European Molecular Biology Organization.   

** Total direct and indirect costs rounded to nearest $1,000 or as shown. 

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Professional Activities:

Memberships:
American Chemical Soc., American Soc. for Photobiology, Inter-American Photochemical Soc., American Chemical Soc-Chicago Chapter SEED Committee (1991-2000).

Review Panels:
National Institutes for General Medical Sciences (NIGMS), Grant Peer Reviewer, MBRS Study Section, Bethesda, MD, March 28-9, 1999.

National Institutes for General Medical Sciences (NIGMS), Grant Peer Reviewer, MBRS Study Section, Bethesda, MD, February 1998.

National Institutes for General Medical Sciences (NIGMS), Grant Peer Reviewer, MBRS Study Section, Bethesda, MD, November, 1997.

Member, NIH Study Section, NIGMS  MS to PhD Linkage Initiatives, Bethesda, MD, March 31- April 1, 1994.

Site reviewer, NIH MBRS Study Section, Bethesda, MD, January 20-22, 1991.

Member, NIH Study Section, NIGMS MS to PhD Linkage Initiatives, Bethesda, MD, July 22-3, 1992.

Site reviewer, NIH MBRS Study Section, September  19 – 20,1991. 

Grant proposal reviewer, American Chemical Society - Petroleum Research Fund, 1980-91.

Editorial reviewer for: BIOCHIMICA  et  BIOPHYSICA ACTA;  PHOTOCHEMISTRY and PHOTOBIOLOGY.

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History Of Research Publications:

1. Cohen, S.G. and Sherman, W.V. (1963) `Inhibition and quenching of the light-induced reduction of benzophenone to benzpinacol and benzhydrol',  Journal of the American Chemical Society, 85, 1642 - 1647.

2. Sherman, W.V. and Williams, G.H. (1963) `Homolytic reactions of aromatic side chains', Journal of the Chemical Society, 1442-1446.

3. Berman, J., Sherman, W.V. and Cohen, S.G. (1963) `Sensitization  and catalysis of the light-induced decarbonylation of aldehydes', Journal of the American Chemical Society, 85, 4010 - 4013.

4. Sherman, W.V. (1964) `Effects of aromatic compounds on the radiolysis of cyclohexane', Chemistry and Industry, 28, 1266 -1268.

5. Sherman, W.V. and Cohen, S.G. (1964) `Flash photolysis of benzophenone in 2-propanol: Effect of phenyl disulfide', Journal of Physical Chemistry, 70, 178 - 182.

6. Sherman, W.V. and Cohen, S.G. (1964) `Hydrogen transfer and energy transfer in the gamma-radiolysis of benzophenone in 2-propanol',  Journal of the American Chemical Society, 86, 1390 - 1393.

7. Cohen, S.G. Laufer, D. and Sherman, W.V. (1964) `Inhibition of light-induced reactions of mercaptans and disulfides', Journal of the American Chemical Society, 86, 3060 - 3065.

8. Sherman, W.V. (1966) `The gamma-radiolysis of 2-propanol. II.      Reaction of solvated electrons with mono- and disubstituted benzenes',  Journal of Physical Chemistry, 70, 2872 - 2875.

9. Sherman, W.V. (1966) `The gamma-radiolysis of 2-propanol.  Effect of nitrous oxide and sulfuric acid', Journal of Physical Chemistry, 70, 667 - 669.

10. Sherman, W.V. (1966) `The reactivity of electrons produced in the gamma-radiolysis of aliphatic alcohols',  Journal of the American Chemical Society, 88,1567 - 1569.

11. Sherman, W.V. (1966) `The photosensitized decomposition of nitrous oxide in alkaline methanolic solution.  A chain reaction resulting in the formation of molecular hydrogen', Chemical Communications, 790 - 793.

12. Sherman, W.V. (1966) `Radiation-induced chain reactions in alkaline solutions of nitrous oxide in aliphatic alcohols', Chemical Communications, 250 - 252.

13. Sherman, W.V. (1965) `Radiation chemistry of solutions of chloromethanes in cyclohexane', Chemical Communications, 489 - 491.

14. Sherman, W.V. (1964) `Correlation between electron affinity and protection in the radiolysis of aliphatic hydrocarbons', Nature, 210, 5042 - 5043.

15. Sherman, W.V. (1966) `Solute effects in the radiolysis of cyclohexane solutions. Part II. Electron scavenging by nitrous oxide and aromatic compounds',  Journal of the Chemical Society (A), 59 - 603.

16. Sherman, W.V. (1965) `Solute effects in the radiolysis of cyclohexane solutions: Effect of substituted aromatic compounds', Journal of the American Chemical Society, 86, 5402 - 54-6.

17. Hentz, R.R., Mellows, R. and Sherman, W.V. (1967) `The effect of water on hydrogen yields in the gamma-radiolysis of 1,4-dioxane', Journal of Physical Chemistry, 71, 3365 - 3370.

18. Sherman, W.V. (1967) `Light-induced and radiation-induced reactions in methanol', Journal of Physical Chemistry, 72, 3365 -3369.

19. Sherman, W.V. (1967) `Photosensitized chain reactions in alkaline solutions of nitrous oxide in 2-propanol',  Journal of the American Chemical Society, 89, 1302 - 1306.

20. Sherman, W.V. (1967) `The gamma-radiolysis of 2-propanol. III.   Chain reactions in alkaline solutions containing nitrous oxide', Journal of Physical Chemistry, 71, 1695 - 1698.

21. Sherman, W.V. (1968) `Radiation-induced oxidation of 2-propanol by dialkyl peroxide', Journalof the American Chemical Society, 90, 6773 - 6776.

22. Sherman, W.V. (1968) `Radical-initiated chain dehalogenation in alkaline alcohol solutions', Journal of Physical Chemistry, 72, 2287 - 2290.

23. Hentz, R.R. and Sherman, W.V. (1968) `Mechanism of hydrogen formation in the radiolysis of dioxane and its mixtures with water', Journal of Physical Chemistry, 72, 2635 - 2638.

24. Hentz, R.R. and Sherman, W.V. (1969) `Charge scavenging and energy transfer in the radiolysis of benzene solutions', Journal of Physical Chemistry, 73, 2676-2680.

25. Sherman, W.V. (1969) `Free radical intermediates in the radiation chemistry of organic compounds', in  ADVANCES IN FREE RADICAL CHEMISTRY, Volume III, Williams, G.H., editor, Academic Press, New York, pages 1 - 88.26.

26. Radlowski, C.* and Sherman, W.V. (1970) `The gamma radiolysis of 2-propanol.  V. Oxidation by carbon tetrachloride', Journal of Physical Chemistry, 74, 3403-3408*.

27. Evans, R.*, Nesyto, E.*, Radlowski, C*. and Sherman, W.V. (1971) `Mechanism of radiation-induced dechlorination of DDT', Journal of Physical Chemistry, 75, 2762-2766*.

28. Evans, R*., Nesyto, E*., Radlowski, C*. and Sherman, W.V. (1971) `Ionizing radiation as a means of dechlorination of DDT', Nature, 232, 118-120*.

29. Backlin, R*. and Sherman, W.V. (1971) `Photochemical dehalogenation of halobenzenes in alkaline alcoholic solution', Chemical Communications, 453-455*.

30.  Sherman, W.V. and Caplan, S.R. (1975) "Arrhenius parameters of phototransients in Halobacterium halobium under physiological conditions", Nature, 258, 766-8.31.  Sherman, W.V.,Slifkin, M.A. and Caplan, S.R. (1976) "Kinetic studies of phototransients in bacteriorhodopsin", Biochimica et Biophysica Acta, 423, 238-248.

32.  Sherman, W.V., Korenstein, R. and Caplan, S.R. (1976) "Energetics and chronology of phototransients in the light response of the purple membrane of Halobacterium halobium", Biochimica et Biophysica Acta, 430, 454-458.

33.   Korenstein, R., Sherman,  W.V. and Caplan, S.R. (1976) "Kinetic isotope effects in the photochemical cycle of bacteriorhodopsin", Biophysics of Structure and Mechanism, 2, 267-276.

34.   Sherman, W.V.  and Caplan, S.R. (1977)  "Chromophore mobility in bacteriorhodopsin", Nature, 265, 273-276.

35. Sherman, W.V. and Caplan, S.R. (1978) "Influence of membrane lipids on the photochemistryof bacteriorhodopsin in the purple membrane of Halobacterim halobium", Biochimica et Biophysica Acta, 502, 222-231.

36. Slifkin, M. A. , Duggan, M. A. , Garty, H. and Sherman, W. V.  (1978) `Measurement of Debye rotational relaxation times of purple membrane fragments by absorbance using a modulation excitation spectro­pho­tometer', Advances in Molecular Relaxation and Interac­tion Processes, 13, 351-353.

37. Sherman, W. V. , Eicke, R. R. , Stafford, S. R.  and Wasacz, F. M.  (1979)`Branching in the bacteriorhodopsin photochemical cycle', Photochemistry & Photobiology, 30, 727-729.*

38. Slifkin, M. A. , Garty, H. , Sherman, W. V.  and Caplan, S. R.  (1979) `Modulation-exci­tation spectrophotometry of bacteriorhodops­in', International Journal of Biological Macromolecules, 1,61-64.

39. Sherman, W. V. , Slifkin, M. A. , Kushlevsky, A. P.  and Parker, S. A. H.  (1979) `Bleaching of the bacteriorhodpsin chromoph­ore by ionizing radiation', International Journal of Radiation Biology, 36, 11-17.

40. Slifkin, M. A. , Garty, H. , Sherman, W. V. , Vincent, M. F. P.  and Caplan, S. R. (1979) `Light-induced conductivity changes in purple membrane suspensions'  Biophysics of  Structure and  Mechanism, 5, 313-320.

41. Slifkin, M. A. , Garty, H. , Sherman, W. V. and Caplan, S. R. (1979) `Modulation excitation spectrophotometry of bacteriorhodops­in' International Journal of Biology, 1, 61 - 64.

42. Grossweiner, L. I.  and Sherman, W. V.  (1980)`The effect of dark complexing on the photosensitized formation of 8-methoxyypsoralen crosslinks with DNA', Photochemistry & Photobiology, 32, 697-699.

43. Sherman, W. V.  and Grossweiner, L. I.  (1981) `Photobinding of psoralen to calf-thymus DNA', Photochemistry & Photobiology, 34, 579-603.

44. Sherman, W. V.  (1981)`Ultraviolet fluorescence of bacterior­hod­opsin and location of tryptophanyl residues', Photochemistry & Photobio­ogy, 33, 367-371.

45. Sherman, W. V.  (1982) `Time-resolved fluorometry of bacteriorhodopsin', Photochemistry and Photobiology', 36, 463-469.

46. Plotkin, B. J.  and Sherman, W. V.  (1984) `Spectral heteroge­neity in protein fluorescence of bacteriorhodopsin' Biochemistry, 23, 5353 - 5­360.

47. Plotkin , B. J. , Boyd, M. S.* , Palmer, P. L.  and Sherman, W. V.  (1985) `Temperature dependence of the phototactic response of Halobact­erium halobium', Current Microbiology, 12, 97-100.*

48. Palmer, P. L.*  and Sherman W. V.  (1985) `Alkaline quenching of bacterio­rhodopsin tryptophanyl fluorescence: Evidence for aqueous accessibility or a hydrogen-bonded chain',Photochemistry and Photo­biology, 42, 541-547. *

49. Plotkin, B. J.  and Sherman, W. V.  (1986) `Photomodulation of the Chemosensory response of Halobacterium halobium',Current Microbiology, 13, 209-213.

50. Sherman, W. V.  and Plotkin, B. J.  (1988) `Tactic responses of Halobact­erium halobium to light and chemical stimuli', in `Biophys­ical Studies of Retinal Proteins', ed.  Ebrey, T. G. , Frauenfelder, H. , Honig, B.  and Nakanishi, K. , University of Illinois Press, 44-51.

51. Sherman, W.V. (1993) `Minorities in Science: The Dialogue', Science, 259 (February 19, 1993), 1105-6.

______________________________________________________________________________
* CSU undergraduate as co-author.

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