Warren V. Sherman, Ph.D.
Professor of Chemistry, Emeritus
The MBRS Program. Since 1991 I have been Program Director of the Minority Biomedical Research Support (MBRS) Programs which are among the largest research grants in the sciences at Chicago State University (CSU). The MBRS programs are funded by the National Institutes of Health (NIH). CSU receives funding for two MBRS Programs: SCORE supports faculty research projects with funding through 2011, and RISE is a training grant preparing students for careers in biomedical research. RISE is funded through 2008 and a renewal application is currently under review for funding through 2012. Since 2000, the MBRS Programs have provided Chicago State with research and research training funds in excess of $14 million.
....... New NIH guidelines exclude emeritus faculty from the role of Program Director for the MBRS programs and starting 2007 Dr Rachel Lindsey assumed that title and I assist her in the role of day-today direction of the program.
Teaching. My teaching has been primarily in areas of organic chemistry and instrumental methods.
Research. My research has received financial support from the federal government (National Institutes of Health, National Science Foundation), the American Chemical Society, the European Molecular Biology Organization and the private sector (International Minerals and Chemicals, Inc., Blum-Kovler Foundation). These activities have resulted in 50 publications in peer-reviewed scientific journals and a larger number of presentations at professional conferences. A significant proportion of these included CSU students as coauthors. My research interests include
- photochemistry and photobiology of biological and synthetic pigments, including rhodopsins,
- protein structural analysis using spectrophotometric techniques,
- photochemistry and high-energy radiation chemistry of organic compounds in solution,
- bacterial phototaxis and chemotaxis, and
- radiation safety and biohazards.
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AWARDS & HONORS:
Fulbright Fellowship, 1961-2.
National Academy of Science Fellowship, US Army Natick Laboratories, Natick, MA, 1962-4.
European Molecular Biology Fellowship at University of Salford, UK, and Weizmann Institute, Israel, 1975-6.
Visiting Professor of Physics, NSF Faculty Development Fellowship, Illinois Institute of Technology, 1979-80.
Faculty Excellence Awards, Chicago State University, 1991, 1992, 1993,1995, and 1999.
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EDUCATION/TRAINING:
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INSTITUTION AND LOCATION
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DEGREE |
FIELD OF STUDY |
| King’s College, University of London |
B.Sc. (Hons.) |
Chemistry |
King’s College, University of London |
Ph.D. |
Organic Chemistry |
Brandeis University |
Postdoctoral |
Photochemistry |
RESEARCH GRANTS & SUPPORT (Director/Principal Investigator): |
DATES |
AGENCY* |
ABBREVIATED TITLE |
BUDGET** |
2008-12 |
NIH-NIGMA |
MBRS-RISE Student Development Program (Associate PD). Application under review. |
$2.9 million (requested) |
2007-11 |
NIH-NIGMS |
MBRS-SCORE Institutional Biomedical Research Program (PD). |
$2.7 million |
2003-7 |
NIH-NIGMS |
MBRS-SCORE Institutional Biomedical Research Program (PD). |
$4.2 million |
2003-8 |
NIH-NIGMS |
MBRS-RISE Student Development Program (PD). |
$2.7 million |
1999-2003 |
NIH-NIGMS |
MBRS-SCORE Institutional Biomedical Research Program (PD). |
$2.4 million |
1999-2003 |
NIH-NIGMS |
MBRS-RISE Student Development Program (PD). |
$2.6 million |
1999-2001 |
NIH-NIGMS |
MBRS-RISE Communications Technology Supplement (PD). |
$246,000 |
2001-4 |
NSF |
Virtual Experiments for Biomedical Engineering Education – joint project with Illinois Institute of Technology (Dr. Ali Cinar, PD). |
$39,000 |
1995-9 |
NIH-NIGMS |
MBRS Institutional Research Grant (PD). |
$3.5 million |
1995-9 |
NIH-NIGMS |
MBRS research project PI: Design and function of sensitizers for photodynamic action. |
$417,376 |
1985-1998
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ACS |
SEED grant for disadvantaged high-school student summer research experience. |
$6,000 (per year) |
1993-6 |
NIH-NCRR |
Minority High School Student Research Apprentice Program. |
$10,000 (per year) |
1991-5 |
NIH-NIGMS |
MBRS research project PI: Design and function of sensitizers for photodynamic action. |
$350,000 |
1987-91 |
NIH-NIGMS |
MBRS research project PI: Photochemistry of bacteriorhodopsin |
$311,203 |
1983-7 |
NIH-NIGMS |
MBRS research project PI: Photochemistry of bacteriorhodopsin |
$96,782 |
1977-82 |
NIH-NIGMS |
MBRS research project PI: Photochemistry of bacteriorhodopsin |
$48,362 |
1981-4 |
NIH - NEI |
RO1 research grant: Photochemistry of visual pigments (renewal) |
$350,000 |
1977-81 |
NIH - NEI |
RO1 research grant: Photochemistry of visual pigments. |
$350,000 |
1984 |
NIH |
Capital instrumentation (FTIR spectrophotometer) |
$50,278 |
1981 |
NSF |
Capital instrumentation (UV-visible scanning spectrophotometer) |
$27,800 |
1988-90 |
IMC |
Industrial research grant (International Minerals & Chemicals) Corp.: Conformational analysis of somatotropins. |
$22,000 |
1980-1 |
NSF |
Faculty Development Award (sabbatical at Illinois Institute of Technology). |
Salary |
1975-6 |
EMBO |
Visiting Research Professor (University of Salford and Weizmann Institute) |
Travel & salary |
1969-71 |
ACS |
Petroleum Research Fund: Radiolysis of organic compounds in solution. |
$25,000 |
* NIH - National Institutes of Health; NIGMS - National Institute of General Medical Sciences; ACS - American Chemical Society; NCI - National Cancer Institute; MBRS - Minority Biomedical Research Support; SEED - Summer Research Experience for Economically Disadvantaged; NSF - National Science Foundation.
** Total direct and indirect costs rounded to nearest $1,000 or as shown. |
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PROFESSIONAL ACTIVITIES:
Memberships:
American Chemical Soc., American Soc. for Photobiology, Inter-American Photochemical Soc., American Chemical Soc-Chicago Chapter SEED Committee (1991-2000).
Review Panels:
National Institutes for General Medical Sciences (NIGMS), Grant Peer Reviewer, MBRS Study Section, Bethesda, MD, March 28-9, 1999.
National Institutes for General Medical Sciences (NIGMS), Grant Peer Reviewer, MBRS Study Section, Bethesda, MD, February 1998.
National Institutes for General Medical Sciences (NIGMS), Grant Peer Reviewer, MBRS Study Section, Bethesda, MD, November, 1997.
Member, NIH Study Section, NIGMS MS to PhD Linkage Initiatives, Bethesda, MD, March 31- April 1, 1994.
Site reviewer, NIH MBRS Study Section, Bethesda, MD, January 20-22, 1991.
Member, NIH Study Section, NIGMS MS to PhD Linkage Initiatives, Bethesda, MD, July 22-3, 1992.
Site reviewer, NIH MBRS Study Section, September 19 – 20,1991.
Grant proposal reviewer, American Chemical Society - Petroleum Research Fund, 1980-91.
Editorial reviewer for: BIOCHIMICA et BIOPHYSICA ACTA; PHOTOCHEMISTRY and PHOTOBIOLOGY.
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RESEARCH PUBLICATIONS:
1. Cohen, S.G. and Sherman, W.V. (1963) `Inhibition and quenching of the light-induced reduction of benzophenone to benzpinacol and benzhydrol', Journal of the American Chemical Society, 85, 1642 - 1647.
2. Sherman, W.V. and Williams, G.H. (1963) `Homolytic reactions of aromatic side chains', Journal of the Chemical Society, 1442-1446.
3. Berman, J., Sherman, W.V. and Cohen, S.G. (1963) `Sensitization and catalysis of the light-induced decarbonylation of aldehydes', Journal of the American Chemical Society, 85, 4010 - 4013.
4. Sherman, W.V. (1964) `Effects of aromatic compounds on the radiolysis of cyclohexane', Chemistry and Industry, 28, 1266 -1268.
5. Sherman, W.V. and Cohen, S.G. (1964) `Flash photolysis of benzophenone in 2-propanol: Effect of phenyl disulfide', Journal of Physical Chemistry, 70, 178 - 182.
6. Sherman, W.V. and Cohen, S.G. (1964) `Hydrogen transfer and energy transfer in the gamma-radiolysis of benzophenone in 2-propanol', Journal of the American Chemical Society, 86, 1390 - 1393.
7. Cohen, S.G. Laufer, D. and Sherman, W.V. (1964) `Inhibition of light-induced reactions of mercaptans and disulfides', Journal of the American Chemical Society, 86, 3060 - 3065.
8. Sherman, W.V. (1966) `The gamma-radiolysis of 2-propanol. II. Reaction of solvated electrons with mono- and disubstituted benzenes', Journal of Physical Chemistry, 70, 2872 - 2875.
9. Sherman, W.V. (1966) `The gamma-radiolysis of 2-propanol. Effect of nitrous oxide and sulfuric acid', Journal of Physical Chemistry, 70, 667 - 669.
10. Sherman, W.V. (1966) `The reactivity of electrons produced in the gamma-radiolysis of aliphatic alcohols', Journal of the American Chemical Society, 88,1567 - 1569.
11. Sherman, W.V. (1966) `The photosensitized decomposition of nitrous oxide in alkaline methanolic solution. A chain reaction resulting in the formation of molecular hydrogen', Chemical Communications, 790 - 793.
12. Sherman, W.V. (1966) `Radiation-induced chain reactions in alkaline solutions of nitrous oxide in aliphatic alcohols', Chemical Communications, 250 - 252.
13. Sherman, W.V. (1965) `Radiation chemistry of solutions of chloromethanes in cyclohexane', Chemical Communications, 489 - 491.
14. Sherman, W.V. (1964) `Correlation between electron affinity and protection in the radiolysis of aliphatic hydrocarbons', Nature, 210, 5042 - 5043.
15. Sherman, W.V. (1966) `Solute effects in the radiolysis of cyclohexane solutions. Part II. Electron scavenging by nitrous oxide and aromatic compounds', Journal of the Chemical Society (A), 59 - 603.
16. Sherman, W.V. (1965) `Solute effects in the radiolysis of cyclohexane solutions: Effect of substituted aromatic compounds', Journal of the American Chemical Society, 86, 5402 - 54-6.
17. Hentz, R.R., Mellows, R. and Sherman, W.V. (1967) `The effect of water on hydrogen yields in the gamma-radiolysis of 1,4-dioxane', Journal of Physical Chemistry, 71, 3365 - 3370.
18. Sherman, W.V. (1967) `Light-induced and radiation-induced reactions in methanol', Journal of Physical Chemistry, 72, 3365 -3369.
19. Sherman, W.V. (1967) `Photosensitized chain reactions in alkaline solutions of nitrous oxide in 2-propanol', Journal of the American Chemical Society, 89, 1302 - 1306.
20. Sherman, W.V. (1967) `The gamma-radiolysis of 2-propanol. III. Chain reactions in alkaline solutions containing nitrous oxide', Journal of Physical Chemistry, 71, 1695 - 1698.
21. Sherman, W.V. (1968) `Radiation-induced oxidation of 2-propanol by dialkyl peroxide', Journalof the American Chemical Society, 90, 6773 - 6776.
22. Sherman, W.V. (1968) `Radical-initiated chain dehalogenation in alkaline alcohol solutions', Journal of Physical Chemistry, 72, 2287 - 2290.
23. Hentz, R.R. and Sherman, W.V. (1968) `Mechanism of hydrogen formation in the radiolysis of dioxane and its mixtures with water', Journal of Physical Chemistry, 72, 2635 - 2638.
24. Hentz, R.R. and Sherman, W.V. (1969) `Charge scavenging and energy transfer in the radiolysis of benzene solutions', Journal of Physical Chemistry, 73, 2676-2680.
25. Sherman, W.V. (1969) `Free radical intermediates in the radiation chemistry of organic compounds', in ADVANCES IN FREE RADICAL CHEMISTRY, Volume III, Williams, G.H., editor, Academic Press, New York, pages 1 - 88.26.
26. Radlowski, C.* and Sherman, W.V. (1970) `The gamma radiolysis of 2-propanol. V. Oxidation by carbon tetrachloride', Journal of Physical Chemistry, 74, 3403-3408*.
27. Evans, R.*, Nesyto, E.*, Radlowski, C*. and Sherman, W.V. (1971) `Mechanism of radiation-induced dechlorination of DDT', Journal of Physical Chemistry, 75, 2762-2766*.
28. Evans, R*., Nesyto, E*., Radlowski, C*. and Sherman, W.V. (1971) `Ionizing radiation as a means of dechlorination of DDT', Nature, 232, 118-120*.
29. Backlin, R*. and Sherman, W.V. (1971) `Photochemical dehalogenation of halobenzenes in alkaline alcoholic solution', Chemical Communications, 453-455*.
30. Sherman, W.V. and Caplan, S.R. (1975) "Arrhenius parameters of phototransients in Halobacterium halobium under physiological conditions", Nature, 258, 766-8.31. Sherman, W.V.,Slifkin, M.A. and Caplan, S.R. (1976) "Kinetic studies of phototransients in bacteriorhodopsin", Biochimica et Biophysica Acta, 423, 238-248.
32. Sherman, W.V., Korenstein, R. and Caplan, S.R. (1976) "Energetics and chronology of phototransients in the light response of the purple membrane of Halobacterium halobium", Biochimica et Biophysica Acta, 430, 454-458.
33. Korenstein, R., Sherman, W.V. and Caplan, S.R. (1976) "Kinetic isotope effects in the photochemical cycle of bacteriorhodopsin", Biophysics of Structure and Mechanism, 2, 267-276.
34. Sherman, W.V. and Caplan, S.R. (1977) "Chromophore mobility in bacteriorhodopsin", Nature, 265, 273-276.
35. Sherman, W.V. and Caplan, S.R. (1978) "Influence of membrane lipids on the photochemistryof bacteriorhodopsin in the purple membrane of Halobacterim halobium", Biochimica et Biophysica Acta, 502, 222-231.
36. Slifkin, M. A. , Duggan, M. A. , Garty, H. and Sherman, W. V. (1978) `Measurement of Debye rotational relaxation times of purple membrane fragments by absorbance using a modulation excitation spectrophotometer', Advances in Molecular Relaxation and Interaction Processes, 13, 351-353.
37. Sherman, W. V. , Eicke, R. R. , Stafford, S. R. and Wasacz, F. M. (1979)`Branching in the bacteriorhodopsin photochemical cycle', Photochemistry & Photobiology, 30, 727-729.*
38. Slifkin, M. A. , Garty, H. , Sherman, W. V. and Caplan, S. R. (1979) `Modulation-excitation spectrophotometry of bacteriorhodopsin', International Journal of Biological Macromolecules, 1,61-64.
39. Sherman, W. V. , Slifkin, M. A. , Kushlevsky, A. P. and Parker, S. A. H. (1979) `Bleaching of the bacteriorhodpsin chromophore by ionizing radiation', International Journal of Radiation Biology, 36, 11-17.
40. Slifkin, M. A. , Garty, H. , Sherman, W. V. , Vincent, M. F. P. and Caplan, S. R. (1979) `Light-induced conductivity changes in purple membrane suspensions' Biophysics of Structure and Mechanism, 5, 313-320.
41. Slifkin, M. A. , Garty, H. , Sherman, W. V. and Caplan, S. R. (1979) `Modulation excitation spectrophotometry of bacteriorhodopsin' International Journal of Biology, 1, 61 - 64.
42. Grossweiner, L. I. and Sherman, W. V. (1980)`The effect of dark complexing on the photosensitized formation of 8-methoxyypsoralen crosslinks with DNA', Photochemistry & Photobiology, 32, 697-699.
43. Sherman, W. V. and Grossweiner, L. I. (1981) `Photobinding of psoralen to calf-thymus DNA', Photochemistry & Photobiology, 34, 579-603.
44. Sherman, W. V. (1981)`Ultraviolet fluorescence of bacteriorhodopsin and location of tryptophanyl residues', Photochemistry & Photobioogy, 33, 367-371.
45. Sherman, W. V. (1982) `Time-resolved fluorometry of bacteriorhodopsin', Photochemistry and Photobiology', 36, 463-469.
46. Plotkin, B. J. and Sherman, W. V. (1984) `Spectral heterogeneity in protein fluorescence of bacteriorhodopsin' Biochemistry, 23, 5353 - 5360.
47. Plotkin , B. J. , Boyd, M. S.* , Palmer, P. L. and Sherman, W. V. (1985) `Temperature dependence of the phototactic response of Halobacterium halobium', Current Microbiology, 12, 97-100.*
48. Palmer, P. L.* and Sherman W. V. (1985) `Alkaline quenching of bacteriorhodopsin tryptophanyl fluorescence: Evidence for aqueous accessibility or a hydrogen-bonded chain',Photochemistry and Photobiology, 42, 541-547. *
49. Plotkin, B. J. and Sherman, W. V. (1986) `Photomodulation of the Chemosensory response of Halobacterium halobium',Current Microbiology, 13, 209-213.
50. Sherman, W. V. and Plotkin, B. J. (1988) `Tactic responses of Halobacterium halobium to light and chemical stimuli', in `Biophysical Studies of Retinal Proteins', ed. Ebrey, T. G. , Frauenfelder, H. , Honig, B. and Nakanishi, K. , University of Illinois Press, 44-51.
51. Sherman, W.V. (1993) `Minorities in Science: The Dialogue', Science, 259 (February 19, 1993), 1105-6.
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* CSU undergraduate as co-author.
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