Preparation of Self-Healing Acrylic Bone Cement Composites

Dr. LeRoy Jones II
Department of Chemistry and Physics

Dr. LeRoy Jones IIAcrylic bone cement is currently the predominant synthetic biomaterial used for anchoring the prosthesis to the contiguous bone in a cemented arthroplasty.  In these joint replacements, the cement mantle should, among other things, allow the transfer of body weight and service loads from the prosthesis to the bone and/or increase the load-carrying capacity of the prosthesis-bone cement-bone system.  It is well recognized, however, that the bone cement mantle often experiences fatigue fracture – due to the propagation of cracks that emanate from, for example, entrapped air bubbles, blood inclusion, etc. – which may ultimately lead to aseptic loosening of the prosthesis.  The goal of the proposed exploratory project is to develop and examine the feasibility of using autonomous agents in acrylic bone cement composites.

Autonomous agents, sometimes referred to as self-healing materials, possess the ability to heal cracks autonomically and, hence, recover the structural function of the component.  It is the hypothesis of the proposed work that the incorporation of autonomous agents into an acrylic bone cement matrix will increase the cement's fracture toughness and fatigue life significantly, while markedly decreasing the rate of propagation of cracks through it.  Accordingly, the specific aims of the proposed research are to (1) incorporate autonomous agents into acrylic bone cement (to obtain self-healing bone cement composites), (2) develop new self-healing chemistries for acrylic bone cements, and (3) determine the mechanical properties of these composites. 

The joint integration of the three specific aims will provide the groundwork for a new group of acrylic bone cement composites.  More importantly, successful achievement of the goal of this developmental project will significantly increase the in vivo longevity of cemented joint replacements which will, in turn, translate to increased patient satisfaction and decreased hospital costs.  The collaborative project will also create opportunities for women and underrepresented minority students to participate actively in the fields of synthetic polymer chemistry, biomechanical engineering and biomaterial research.

Tyvette Hilliard at the 2006 ABRCMS Conference Students working in Dr. Jones laboratory
RISE alumna Tyvette Hilliard presenting
her research.
RISE students LaDeia Dunlap (left) and Sonya Blackman working in Dr. Jones' lab.
Jones research group picture with Professor Gladius Lewis
RISE students with project consultant Dr. Gladius Lewis, Professor of Mechanical Engineering, University of Memphis.

Recent Student Presentations

(RISE students are identified in boldface)

John Davis, Max Ukaigwe and LeRoy Jones II, "PREPARATION AND CHARACTERIZATION OF BINARY AND TERTIARY NANOPARTICLES FROM MICROEMULSIONS"  19th ANNUAL ILLINOIS STUDENT RESEARCH CONFERENCE, Western Illinois University, Macomb, Illinois, March 28-9, 2008.

John Davis, Maxamus Ukaigwe and LeRoy Jones II, "PREPARATION AND CHARACTERIZATION OF BIMETALLIC NANOPARTICLES FROM MICROEMULSIONS", 10TH ANNUAL ILLINOIS STOKES ALLIANCE FOR MINORITY PARTICIPATION STUDENT RESEARCH CONFERENCE , Glenview, Illinois, October 12-13, 2007.

Patrick Biggs and LeRoy Jones II, "Incorporation of microencapsulated dicyclopentadiene into an acrylic bone cement matrix" Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007 (2007), INOR-283.

Pablo Guzman and LeRoy Jones II, "Synthesis of ruthenium bidentate Schiff-base complexes via microwave irradiation" Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007 (2007), INOR-963

Tyvette Hilliard and LeRoy Jones II, "Preparation of half-metallocene catalysts for biomedical applications" Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007 (2007), INOR-410.

Pablo Guzman and LeRoy Jones II, PREPARATION OF RUTHENIUM BIDENTATE SCHIFF-BASE COMPLEXES VIA MICROWAVE IRRADIATION, 2006 Annual Biomedical Research Conference for Minority Students (ABRCMS), Anaheim, CA, November 8 - 11, 2006.

Tyvette Hilliard and LeRoy Jones II, DESIGN AND SYNTHESIS OF HALF-METALLOCENE CATALYSTS FOR BIOMEDICAL APPLICATIONS, 2006 Annual Biomedical Research Conference for Minority Students (ABRCMS), Anaheim, CA, November 8 - 11, 2006.

Sonya Blackman, LeRoy Jones II, Gladius Lewis and Patrick Biggs, SYNTHESIS AND EVALUATION OF AUONOMOUS HEALING AGENTS FOR BONE CEMENTS, 2006 Annual Biomedical Research Conference for Minority Students (ABRCMS), Anaheim, CA, November 8 - 11, 2006.

Pablo E. Guzman and LeRoy Jones II, PREPARATION OF RUTHENIUM BIDENTATE SCHIFF-BASE COMPLEXES VIA MICROWAVE IRRADIATION, 19th Annual Illinois Alliance for Minority Participation (AMP) Student Research Conference, Glenview, IL, October 6-7, 2006

Sonya Blackman, LeRoy Jones II, Patrick Biggs and  Gladius Lewis, SYNTHESIS AND EVALUATION OF AUTONOMOUS HEALING AGENTS FOR BONE CEMENT, 19th Annual Illinois Alliance for Minority Participation (AMP) Student Research Conference, Glenview, IL, October 6-7, 2006 

Tyvette Hilliard and LeRoy Jones II, DESIGN AND SYNTHESIS OF NON-METALLOCENE CATALYSTS FOR BIOMEDICAL APPLICATIONS, 19th Annual Illinois Alliance for Minority Participation (AMP) Student Research Conference, Glenview, IL, October 6-7, 2006

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This page was last updated on 01/12/09

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